Aims: This project aims at filling the gap between the measured anticancer activity of Pt(II) and Pd(II) polyamine chelates (in the light of their previously established SAR´s) and their biodistribution and biochemical impact (metabolic and histopathological effects). Furthermore, the effect of common dietary phytochemicals on the pharmacodynamics of the complexes will be investigated, with a view to begin to understand the influence of the daily diet on chemotherapy intervention. The success of this multidisciplinary study is ensured by the recognised expertise of the team members in the different approaches to be used, in a close scientific collaboration between six research institutions (national and international)