PROJECTS - DIETxPosome

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Overview

Through diet we are continuously exposed to a complexity of chemicals including nutrients and contaminants - the dietary exposome - whose impact on chronic inflammation in the context of whole-diet is still poorly understood. The innovative approach of this proposal relies on finding hidden patterns from data available on literature and databases of consumption data, food nutrients composition, or predominant food contaminants to understand without human-in-the-loop processing the profile of prevalent contaminants associated with different dietary patterns. This knowledge will provide essential tools to design optimal experimental procedures for repeated dietary exposome in vitro assays and later to mathematical modelling the complexity of chronic inflammation triggered by dietary-exposome and finally, to validate the predictive model by using a different dietary pattern and contaminant doses to bring new evidence that can refine nutritional guidelines, considering food-chain chemical contaminants exposure and reducing diet related inflammation.

Start / End: 1 Jan 2021 / 31 Dez 2023

Funding Program: National Funding (FCT/MCTES)

Total funding: 249.625,27 €

FFUP: 53.750,00 €

REQUIMTE: 195.875,27 €

Tasks

Publications

DIETxPOSOME scientific publications:

Z.E. Martins, H. Ramos, A.M. Araújo, M. Silva, M. Ribeiro, A. Melo, C. Mansilha, O. Viegas, M.A. Faria, I.M.P.L.V.O. Ferreira. From data to insight: Exploring contaminants in different food groups with literature mining and machine learning techniques. Current Research in Food Science 7 (2023) 100557 doi.org/10.1016/j.crfs.2023.100557. J. Marín-Sáez, R. Lopez-Ruiz, I.M.P.L.V.O. Ferreira, S.C. Cunha. Gastrointestinal bioaccessibility of tropane alkaloids assessed on tea and cookies by in vitro digestion Journal of Science Food and Agriculture 103 (2023) 5539–5546. doi.org/10.1002/jsfa.12627. P. Lopes, M.M.C. Sobral, G.R. Lopes, Z.E. Martins, C.P. Passos , S. Petronilho, I.M.P.L.V.O. Ferreira. Mycotoxins’ Prevalence in Food Industry By-Products: A Systematic Review. Toxins (Basel) 15(4) (2023) 249. I. Azmy Harahap, M.M.C. Sobral, S. Casal, S.C.M. Pinho, M.A. Faria, J. Suliburska, I.M.P.L.V.O. Ferreira. Fat Oxidation of Fatty Fish vs. Meat Meal Diets Under in vitro Standardized Semi-Dynamic Gastric Digestion. Frontiers in Nutrition 9 (2022) 901006. doi.org/10.3389/fnut.2022.901006. R. López-Ruiz, J. Marin-Saez, S.C. Cunha, A. Fernandes, V. Freitas, O. Viegas, I.M.P.L.V.O. Ferreira. Investigating the Impact of Dietary Fibers on Mycotoxin Bioaccessibility during In Vitro Biscuit Digestion and Metabolites Identification. Foods 12 (2023, 3175). https://doi.org/10.3390/foods12173175. J. Marín-Sáez, R. López-Ruiza, M. Sobral, R. Romero-González, A. Garrido-Frenich, I.M.P.L.V.O.Ferreira. Analytical methods for biomonitoring organic chemical hazards in saliva: A systematic review. TrAC Trends in Analytical Chemistry 158 (2023) 116853. M.M. Costa Sobral , T. Gonçalves, Z.E. Martins , C. Bäuerl, E. Cortés-Macías, M.C. Collado, I.M.P.L.V.O. Ferreira. Mycotoxin Interactions along the Gastrointestinal Tract: In Vitro Semi-Dynamic Digestion and Static Colonic Fermentation of a Contaminated Meal. Toxins 14 (2022) 28. https://doi.org/10.3390/toxins14010028. S.C.M. Pinho, M.A. Faria, R. Alves, A.R.J. Cabrita, A.J.M. Fonseca, I.M.P.L.V.O. Ferreira, Gastric epithelial response to milk fat using the semi-dynamic INFOGEST digestion model coupled with NCI-N87 cells. Food Research International 166 (2023) 112576. https://doi.org/10.1016/j.foodres.2023.112576. A. Kondrashina, E. Arranz, A. Cilla, M.A. Faria, M. Santos-Hernández, B. Miralles, N. Hashemi, M.K. Rasmussen, J.F. Young, R. Barberá, G. Mamone, L. Tomás-Cobos, S. Bastiaan-Net, M. Corredig, L. Giblin. Coupling in vitro food digestion with in vitro epithelial absorption; recommendations for biocompatibility. Critical Reviews in Food Science and Nutrition https://doi.org/10.1080/10408398.2023.2214628. A. Hevia, P. Ruas-Madiedo, M. A. Faria, V. Petit, B. Alves, P. Alvito, E. Arranz, S. Bastiaan-Net, M. Corredig, W. Dijk, D. Dupont, L. Giblin, B. A. Graf, A. Kondrashina, H. Ramos, L. Ruiz, M. Santos-Hernández, L. Soriano-Romaní, L. Tomás-Cobos, S. Vivanco-Maroto, I. Recio, B. Miralles. A shared perspective on in vitro and in vivo models to assay intestinal transepithelial transport of food compounds. Journal of Agricultural and Food Chemistry B. Miladinovic, M. Ângelo Faria, M. Ribeiro, M.M. Sobral, I.M.P.L.V.O. Ferreira. Delphinidin-3-rutinoside from Blackcurrant Berries (Ribes nigrum): In Vitro Antiproliferative Activity and Interactions with Other. Molecules 28(3) (2023) 1286. Database: Z.E. Martins, H. Ramos, A.M. Araújo, M. Silva, M. Ribeiro, A. Melo, C. Mansilha, O. Viegas, M.A. Faria, I.M.P.L.V.O. Ferreira DIETxPOSOME - selection of potentially useful papers from literature mining and machine learning protocols. Zenodo (2023) https://doi.org/10.5281/zenodo.7826130. Opinion article: I.M.P.L.V.O. Ferreira "Novas perspetivas em qualidade e segurança dos alimentos". edição de Junho de 2023 de Caderno País Positivo

Dissemination of project results in international conferences:

I.M.P.L.V.O. Ferreira, M. Silva, M. Ribeiro, H. Ramos, A.M. Araújo, A. Melo, C. Mansilha, O. Viegas, M.A. Faria, Z. Martins. Data mining and machine learning methods to predict food contaminants exposure. XXII Congress, EuroFoodChem XXII, Belgrado, Sérvia, 14-16 de Junho 2023 (oral) O. Pinho, S. Sevim, O. Viegas, M.A. Faria, S.C. Cunha, I.M.P.L.V.O. Ferreira. Inhibition of acrylamide in biscuits by fibre supplementation. XXII Congress, EuroFoodChem XXII, Belgrado, Sérvia, 14-16 de Junho 2023 (poster). M.A. Faria, C. Monteiro, H. Ramos, S. Sá, E. Pinto, J.O. Fernandes, S. Cunha, I.M.P.L.V.O. Ferreira. Combined synergic exposure to food contaminants: A matter of concern? XXII Congress, EuroFoodChem XXII, Belgrado, Sérvia, 14-16 de Junho 2023 (oral). Z.E. Martins, M. Silva, A. Melo, C. Mansilha, M.A. Faria, I.M.P.L.V.O. Ferreira. From Data mining to Meta-analysis: Presence of mycotoxins in food. XXII Congress, EuroFoodChem XXII, Belgrado, Sérvia, 14-16 de Junho 2023 (oral). I.M.P.L.V.O. Ferreira. Unveiling food contaminants exposome from different dietary patterns based on scientific data mining and mathematical modelling. GSFST2023, 2nd Global Summit on Food Science and Technology, Rome, 23-25 Março 2023 (Plenary) S.C.M. Pinho. Impact of origin and production system on milk composition and consequent effects on human nutrition and health. 10th International Infogest Viva Webinar on Food Digestion - 5 July 2023, 2pm (Dublin) (webinar). Z. Martins, M. Silva, A. Melo. M. Faria, I.M.P.L.V.O. Ferreira. Application of data mining techniques to unveil contaminants occurrence in food. XXVI Encontro Galego-Portugués de Química. Congreso Internacional, Santiago de Compustela, 16-18 Novembro 2022 (oral). M.M. Sobral, T. Gonçalves, Z.Martins, C. Bäuerl, E. Cortés-Macías, M.C. Collado, I.M.P.L.V.O. Ferreira. Study the fate of mycotoxins along gastrointestinal tract using a semi-dynamic digestion model followed by a static colonic fermentation. 7th International Conference in Food Digestion, ICFD2022, Cork 3-5 May 2022 (oral). I.M.P.L.V.O. Ferreira, I. Azmy Harahap, M.M.Sobral, S.Casal, S. Pinho, J. Suliburska, Miguel Faria. Monitoring fatty acid oxidation of beef and fish meals during gastric digestion using an in vitro semi-dynamic model. 7th International Conference in Food Digestion, ICFD2022, Cork 3-5 May 2022 (poster). S. Zejnelhoxha, O. Viegas, S. Tavaniello, E. Pinto, M. Wu, M. Palazzo, I.M.L.P.V.O Ferreira, G. Maiorano. Polycyclic Aromatic Hydrocarbons (PAHs) in charchoal-grilled beef meat: influence of different concentrations of vitamin E. INTERNATIONAL PhD STUDENT CONFERENCE. Research and Innovation in Agricultural, Livestock and Food Sciences, Campobasso, May, 9-12, 2022 (oral).

Dissemination of project results in national conferences:

I.M.P.L.V.O. Ferreira. Compostos bioativos da dieta mediterânica: estudos in vitro studies and saliva biomonitoring. 2º Congresso da Rede de Instituições de Ensino Superior para a Salvaguarda da Dieta Mediterrânica, 2º Conferência sobre Dieta e Gastronomia Mediterrânicas. A Multidisciplinarideade à mesa, 28 e 29 de Setembro 2023 – Palácio D. Manuel (Mesa redonda). S. Sevim, R. López-Ruiz, J. Marin-Saez, A. Fernandes, O. Viegas, S.C. Cunha, I.M.P.L.V.O. Ferreira. Reduce acrylamide formation in biscuits by fiber enrich the receipt. Dare2change meeting, Porto Superbock Arena, 21 de Março 2023 (poster). A.G. Ramos, O. Viegas, E. Pinto, I.M.P.L.V.O. Ferreira. Salt replacement by Salicornia ramosissima to reduce biogenic amines formation in fish. Dare2change meeting, Porto Superbock Arena, 21 de Março 2023 (poster). Z. Martins, M. Silva, M. Ribeiro, H. Ramos, A.M. Araújo, A. Melo, Carla S. S. Teixeira, O. Viegas, M. Faria, I.M.P.L.V.O. Ferreira. The distribution of contaminants in foods according to the scientific literature data mining and machine learning. Dare2change meeting, Porto Superbock Arena, 21 de Março 2023 (poster). S.C.M. Pinho, M.A. Faria, R.Alves, A.R.J. Cabrita, A.J.M. Fonseca, I.M.P.L.V.O. Ferreira. Whole conventional, whole pasture-based, and fat-free cow’s milk: Effect in mRNA expression of human gastric epithelium. IX Annual Workshop for the Doctoral Program in Animal Science – ICBAS, School of Medicine and Biomedical Science of the University of Porto, 2022 (oral). J. Marín-Sáez, R. López Ruiz, R. Romero González, IMPLVO Ferreira, Sara Cunha. Cereals and pseudocereals contaminated with tropane alkaloids: analytical tools to assure food safety. Transcolab Summit. Trend in grain-based foods, Instituto Politécnico de Bragança, 23-25th March 2022 (oral).

Organization of conferences, courses and seminars:

Seminar - Quality and Safety in Food Supply Chain to Protect Consumers' Health:, Faculty of Pharmacy - University of Porto, 24th May 2023:

DIETxPOSOME project: Exploring contaminants in different food groups with literature mining and machine learning techniques - Z.E. Martins. Combined Exposure to Food Contaminants From Multiple Stages of the Food Supply Chain - M.Faria.

Seminar - Mindful nutrition: knowing both benefits and risks of foods, Faculty of Pharmacy - University of Porto, 23rd May 2022:

Data mining: the emerging digital omics to estimate food composition. Mindful nutrition: knowing both benefits and risks of foods - Z. Martins. Fate of mycotoxins along gastrointestinal tract assessed by in vitro studies. Mindful nutrition: knowing both benefits and risks of foods - M. Sobral. Influence of cooking methods on the content of polycyclic aromatic hydrocarbons and heavy metals - O. Viegas.

EUGLOH Summer School, Nutrition and Food Sciences, 29th June – 2nd July 2021:

How can we contribute to food quality? - I.M.P.L.V.O. Ferreira

The global implication of our food choices: fat matters! – S. Casal

Natural ingredients as suitable alternatives to mitigate formation of hazardous substances in cooked foods – M.M. Sobral

Continuous exposure to complex dietary chemicals and chronic health risks – M. Faria

Events

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